Mikhailachev Manor is about a family of genetically-engineered vampires who not only must try to live life as normal as is possible, but also get along with their human neighbors and somehow prevent their descendants from becoming future vampires. It all starts with Three Brothers named Sergei and his younger brothers Piotr and Pavel when they are forced to leave Russia because they would be destined to be among those Mikhailachevs who would be vampires once they reach adulthood.